Arpeggio Bio YC Application

Summer 2019Active

Arpeggio Bio went through Y Combinator in the Summer 2019 batch as a Healthcare company. Below: what the company does, who founded it, and its application to YC, reconstructed question by question in the real YC form.

YC batch: Summer 2019
Industry: HealthcareDrug Discovery and Delivery
Team size: 20
Status: Active
Launched: 2019

Founders

Joey AzofeifaFounder

What Arpeggio Bio does

Arpeggio Bio is a pioneering pharmaceutical company that develops drugs targeting transcription factors using AI and high-throughput RNA-sequencing. With $20M in venture funding, we've targeted "undruggable" proteins like NRF2, TEAD, and GPX4 where our lead program is rapidly progressing towards a DC for the treatment of IO-resistant melanoma. With partnerships with J&J and FORMA, we've validated our platform in rare disease and inflammation with a significant Phase I success.

Arpeggio Bio's YC application, reconstructed

Y Combinator application

Arpeggio Bio, Summer 2019 batch. The real form questions, answered from public data.

Founders2
Company7
Progress7
Idea4
Equity3
Curious2
Batch Preference1

Company

Company name

Arpeggio Bio

Describe what your company does in 50 characters or less.

Develop drugs targeting transcription factors using AI

What is your company going to make? Please describe your product and what it does or will do.

We build drugs that hit transcription factors - proteins considered "undruggable" - by combining AI-driven approaches with high-throughput RNA-sequencing. Our platform lets us design molecules that modulate targets like NRF2, TEAD, and GPX4, opening treatment options for cancers resistant to existing therapies and rare diseases.

Where do you live now, and where would the company be based after YC?

We live and work in Boulder, CO, and plan to base the company here after YC as well.

Explain your decision regarding location.

Boulder has strong biotech and tech talent for our area. We're set up here with our team and lab space, so staying puts us close to our people and operations.

21 more answers in the full application

Founders, Progress, Idea, Equity, Curious, Batch Preference are in the full version. Create a free account to open it in YC Insights, next to every other YC batch.

See full application

Frequently Asked Questions

Is this the real Arpeggio Bio YC application?

No. Y Combinator keeps submitted applications private. This is a reconstruction: the real YC form questions, answered from Arpeggio Bio's public data (launch notes, founder backgrounds, product description). It shows how a company like Arpeggio Bio would present itself to YC, not the text they submitted.