Origami Therapeutics, Inc.

Origami Therapeutics, Inc. YC Application

Winter 2022Active

Origami Therapeutics, Inc. went through Y Combinator in the Winter 2022 batch as a Healthcare company. Below: what the company does, who founded it, and its application to YC, reconstructed question by question in the real YC form.

YC batch
Winter 2022
Industry
HealthcareTherapeutics
Team size
4
Status
Active
Launched
2022

Founders

  • Beth Hoffman
    Beth HoffmanFounder

What Origami Therapeutics, Inc. does

Origami Therapeutics, Inc. is a biotech company developing novel protein degraders with potential to delay or halt disease progression by eliminating toxic proteins from the body. Our drug discovery platform leverages our proprietary human disease models developed to select the small molecules with the best chance of clinical success. Our first indication is Huntington’s disease, a debilitating, progressive and ultimately fatal disorder caused by a genetic mutation. We have already identified small molecules that reduce the toxic mutated protein, suppress mutant protein-induced toxicities in human disease neurons and get into the brain. We anticipate that this approach will be broadly applicable to traditionally “undruggable” targets in other neurological diseases.

Origami Therapeutics, Inc.'s YC application, reconstructed

Y Combinator application

Origami Therapeutics, Inc., Winter 2022 batch. The real form questions, answered from public data.

  1. Founders2
  2. Company7
  3. Progress7
  4. Idea4
  5. Equity3
  6. Curious2
  7. Batch Preference1

Company

Company name

Origami Therapeutics, Inc.

Describe what your company does in 50 characters or less.

Oral drugs to halt neurodegeneration

What is your company going to make? Please describe your product and what it does or will do.

We develop oral small molecule protein degraders aimed at halting neurodegeneration by removing toxic proteins that cause diseases like Huntington's. We use proprietary human disease models to select molecules that get into the brain and reduce mutant proteins in neurons.

Where do you live now, and where would the company be based after YC?

We live in San Diego, CA and will be based here after YC.

Explain your decision regarding location.

San Diego's biotech ecosystem and access to scientific talent fit our development timeline and goals.

21 more answers in the full application

Founders, Progress, Idea, Equity, Curious, Batch Preference are in the full version. Create a free account to open it in YC Insights, next to every other YC batch.

Frequently Asked Questions

Is this the real Origami Therapeutics, Inc. YC application?

No. Y Combinator keeps submitted applications private. This is a reconstruction: the real YC form questions, answered from Origami Therapeutics, Inc.'s public data (launch notes, founder backgrounds, product description). It shows how a company like Origami Therapeutics, Inc. would present itself to YC, not the text they submitted.

What YC batch was Origami Therapeutics, Inc. in?

Origami Therapeutics, Inc. was part of the Y Combinator Winter 2022 batch.

Who founded Origami Therapeutics, Inc.?

Origami Therapeutics, Inc. was founded by Beth Hoffman.

What does Origami Therapeutics, Inc. do?

Oral drugs to halt neurodegeneration

How do I read the full reconstructed application?

Create a free Round Funded account. The full 26-answer version of Origami Therapeutics, Inc.'s application, and every other YC batch, is in YC Insights.

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