Заявка Cisterna Biologics в YC

Summer 2022Active

Cisterna Biologics прошел Y Combinator в потоке Summer 2022 как компания из сферы Healthcare. Ниже: чем занимается компания, кто ее основал, и ее заявка в YC, реконструированная вопрос за вопросом в реальной форме YC.

Поток YC: Summer 2022
Сфера: Healthcare
Размер команды: 2
Статус: Active
Запущено: 2022

Фаундеры

Hari BhaskaranFounder

Чем занимается Cisterna Biologics

Founded in 2022 and based in San Diego, California, Cisterna Biologics is a technology company. It aims to solve some of the challenges currently facing the biotech industry to develop mRNA-based therapeutics - quality, quantity, longevity and cost of mRNA. As mRNA technology matures, it becomes imperative that these issues are solved so we can fully explore mRNA's endless possibilities as a therapeutic. Cisterna uses proprietary technologies to either remove a contaminant at its source or replace the source itself. For example, to remove double-stranded RNA (dsRNA), we use ribozymes - molecular scissors - to precisely cut the mRNA at its 3’ end. This assures not only 3’ homogeneity, but also eliminates dsRNA, which are primarily produced due to self-templated additions at the 3’ end. Utilizing a PCR-like system to amplify the DNA template in large quantities eliminates the requirement for plasmid enrichment in bacteria, the prime source of endotoxin contamination. These are just a few examples of Cisterna’s powerful technologies being used to achieve our goal of 10x higher quality mRNA for therapeutic application.

Заявка Cisterna Biologics в YC, реконструирована

Заявка Y Combinator

Cisterna Biologics, батч Summer 2022. Реальные вопросы из анкеты, ответы из публичных данных.

Founders2
Company7
Progress7
Idea4
Equity3
Curious2
Batch Preference1

Company

Company name

Cisterna Biologics

Describe what your company does in 50 characters or less.

High quality mRNA for therapeutic use

What is your company going to make? Please describe your product and what it does or will do.

We make mRNA optimized for therapeutic use by solving challenges around quality, quantity, longevity, and cost. Our platform removes contaminants like double-stranded RNA using ribozymes to cut precisely at the mRNA 3' end, ensuring purity and consistency. We also replace bacterial plasmid amplification with a PCR-based system to eliminate endotoxin contamination and scale DNA templates efficiently. This leads to mRNA of substantially higher quality for drug developers tackling diseases amenable to mRNA therapy.

Where do you live now, and where would the company be based after YC?

We live and operate out of San Diego, CA, where the company is also based. After YC, we'd stay here to keep close ties to the biotech ecosystem and our team.

Explain your decision regarding location.

San Diego's biotech community suits our focus on synthetic biology and mRNA therapeutics. It has the scientific talent and lab access we need to keep pushing quality and manufacturing innovations. Relocating after YC would disrupt progress.

21 еще ответ в полной заявке

Founders, Progress, Idea, Equity, Curious, Batch Preference находятся в полной версии. Создайте бесплатную учетную запись, чтобы открыть ее в YC Insights, рядом с каждым другим потоком YC.

Смотреть полную заявку

Часто задаваемые вопросы

Это реальная заявка Cisterna Biologics в YC?

Нет. Y Combinator держит поданные заявки в приватности. Это реконструкция: реальные вопросы формы YC, ответы на которые основаны на публичных данных Cisterna Biologics (заметки о запуске, бэкграунд фаундеров, описание продукта). Это показывает, как компания вроде Cisterna Biologics представила бы себя YC, а не текст, который они подали.