Cisterna Biologics YCアプリケーション

Summer 2022Active

Cisterna BiologicsはSummer 2022バッチでHealthcare企業としてY Combinatorを卒業しました。以下：会社の事業内容、創業者、そして実際のYCフォームで質問ごとに再構築されたYCへの応募内容。

YCバッチ: Summer 2022
業界: Healthcare
チーム規模: 2
ステータス: Active
ローンチ済み: 2022

創業者

Hari BhaskaranFounder

Cisterna Biologicsの事業内容

Founded in 2022 and based in San Diego, California, Cisterna Biologics is a technology company. It aims to solve some of the challenges currently facing the biotech industry to develop mRNA-based therapeutics - quality, quantity, longevity and cost of mRNA. As mRNA technology matures, it becomes imperative that these issues are solved so we can fully explore mRNA's endless possibilities as a therapeutic. Cisterna uses proprietary technologies to either remove a contaminant at its source or replace the source itself. For example, to remove double-stranded RNA (dsRNA), we use ribozymes - molecular scissors - to precisely cut the mRNA at its 3’ end. This assures not only 3’ homogeneity, but also eliminates dsRNA, which are primarily produced due to self-templated additions at the 3’ end. Utilizing a PCR-like system to amplify the DNA template in large quantities eliminates the requirement for plasmid enrichment in bacteria, the prime source of endotoxin contamination. These are just a few examples of Cisterna’s powerful technologies being used to achieve our goal of 10x higher quality mRNA for therapeutic application.

Cisterna BiologicsのYCアプリケーション、再構築済み

Y Combinator 申請

Cisterna Biologics 様、Summer 2022 バッチ。公開データから回答された、実際のフォームの質問。

Founders2
Company7
Progress7
Idea4
Equity3
Curious2
Batch Preference1

Company

Company name

Cisterna Biologics

Describe what your company does in 50 characters or less.

High quality mRNA for therapeutic use

What is your company going to make? Please describe your product and what it does or will do.

We make mRNA optimized for therapeutic use by solving challenges around quality, quantity, longevity, and cost. Our platform removes contaminants like double-stranded RNA using ribozymes to cut precisely at the mRNA 3' end, ensuring purity and consistency. We also replace bacterial plasmid amplification with a PCR-based system to eliminate endotoxin contamination and scale DNA templates efficiently. This leads to mRNA of substantially higher quality for drug developers tackling diseases amenable to mRNA therapy.

Where do you live now, and where would the company be based after YC?

We live and operate out of San Diego, CA, where the company is also based. After YC, we'd stay here to keep close ties to the biotech ecosystem and our team.

Explain your decision regarding location.

San Diego's biotech community suits our focus on synthetic biology and mRNA therapeutics. It has the scientific talent and lab access we need to keep pushing quality and manufacturing innovations. Relocating after YC would disrupt progress.

フルアプリケーションで21件の追加回答

はフルバージョンにあります。無料アカウントを作成して、他のすべてのYCバッチの横にあるYCインサイトで開いてください。

申請内容全体を見る

よくある質問

Cisterna Biologicsの実際のYCアプリケーションですか？

いいえ。Y Combinatorは提出されたアプリケーションを非公開にしています。これは再構築されたものです。実際のYCフォームの質問に、Cisterna Biologicsの公開データ（ローンチノート、創業者経歴、製品説明）から回答しています。Cisterna Biologicsのような会社がYCにどのようにアピールするかを示しており、彼らが提出したテキストではありません。