Candidature YC de Cisterna Biologics

Summer 2022Active

Cisterna Biologics a été sélectionné par Y Combinator dans le cadre du batch Summer 2022 en tant qu'entreprise Healthcare. Ci-dessous : ce que fait l'entreprise, qui l'a fondée, et sa candidature à YC, reconstruite question par question dans le vrai formulaire YC.

Batch YC: Summer 2022
Secteur d'activité: Healthcare
Taille de l'équipe: 2
Statut: Active
Lancé: 2022

Fondateurs

Hari BhaskaranFounder

Ce que fait Cisterna Biologics

Founded in 2022 and based in San Diego, California, Cisterna Biologics is a technology company. It aims to solve some of the challenges currently facing the biotech industry to develop mRNA-based therapeutics - quality, quantity, longevity and cost of mRNA. As mRNA technology matures, it becomes imperative that these issues are solved so we can fully explore mRNA's endless possibilities as a therapeutic. Cisterna uses proprietary technologies to either remove a contaminant at its source or replace the source itself. For example, to remove double-stranded RNA (dsRNA), we use ribozymes - molecular scissors - to precisely cut the mRNA at its 3’ end. This assures not only 3’ homogeneity, but also eliminates dsRNA, which are primarily produced due to self-templated additions at the 3’ end. Utilizing a PCR-like system to amplify the DNA template in large quantities eliminates the requirement for plasmid enrichment in bacteria, the prime source of endotoxin contamination. These are just a few examples of Cisterna’s powerful technologies being used to achieve our goal of 10x higher quality mRNA for therapeutic application.

Candidature YC de Cisterna Biologics, reconstruite

Candidature Y Combinator

Cisterna Biologics, promotion Summer 2022. Les vraies questions de candidature, répondues à partir de données publiques.

Founders2
Company7
Progress7
Idea4
Equity3
Curious2
Batch Preference1

Company

Company name

Cisterna Biologics

Describe what your company does in 50 characters or less.

High quality mRNA for therapeutic use

What is your company going to make? Please describe your product and what it does or will do.

We make mRNA optimized for therapeutic use by solving challenges around quality, quantity, longevity, and cost. Our platform removes contaminants like double-stranded RNA using ribozymes to cut precisely at the mRNA 3' end, ensuring purity and consistency. We also replace bacterial plasmid amplification with a PCR-based system to eliminate endotoxin contamination and scale DNA templates efficiently. This leads to mRNA of substantially higher quality for drug developers tackling diseases amenable to mRNA therapy.

Where do you live now, and where would the company be based after YC?

We live and operate out of San Diego, CA, where the company is also based. After YC, we'd stay here to keep close ties to the biotech ecosystem and our team.

Explain your decision regarding location.

San Diego's biotech community suits our focus on synthetic biology and mRNA therapeutics. It has the scientific talent and lab access we need to keep pushing quality and manufacturing innovations. Relocating after YC would disrupt progress.

21 réponses supplémentaires dans la candidature complète

se trouvent dans la version complète. Créez un compte gratuit pour l'ouvrir dans YC Insights, à côté de tous les autres batches YC.

Voir la candidature complète

Questions fréquemment posées

Est-ce la vraie candidature YC de Cisterna Biologics ?

Non. Y Combinator garde les candidatures soumises privées. Ceci est une reconstruction : les vraies questions du formulaire YC, répondues à partir des données publiques de Cisterna Biologics (notes de lancement, parcours des fondateurs, description du produit). Cela montre comment une entreprise comme Cisterna Biologics se présenterait à YC, pas le texte qu'ils ont soumis.

À quel batch YC Cisterna Biologics appartenait-il ?

Cisterna Biologics faisait partie du batch Summer 2022 de Y Combinator.

Qui a fondé Cisterna Biologics ?

Cisterna Biologics a été fondé par Hari Bhaskaran.

Que fait Cisterna Biologics ?

High quality mRNA for therapeutic application

Comment lire la candidature complète reconstruite ?

Créez un compte Round Funded gratuit. La version complète de la candidature de Cisterna Biologics en 26 réponses, et de chaque autre promotion YC, se trouve dans YC Insights.