XGenomes

XGenomes YC Application

Winter 2019Active

XGenomes went through Y Combinator in the Winter 2019 batch as a Healthcare company. Below: what the company does, who founded it, and its application to YC, reconstructed question by question in the real YC form.

YC batch
Winter 2019
Industry
HealthcareDiagnostics
Team size
6
Status
Active
Launched
2018

Founders

  • Kalim Mir
    Kalim MirFounder/CEO

What XGenomes does

At XGenomes, we are building a technology comprising novel biochemistry, hardware and algorithms for sequencing DNA. Our product will be streamlined: there is zero library preparation; we sequence directly on unadulterated single molecules of DNA; DNA extraction will be integrated with sequencing; there is no bioinformatics bottleneck. The sequence we produce will be of unprecedented accuracy due to several layers of in-built redundancy including the sequencing both strands of the double-helix concurrently. The sequence we produce will be complete, encompassing: structural as well as single nucleotide variants; long-range haplotype phase; the repetitive "dark matter" of the genome. The cost of goods (consumables) of sequencing will be <$10, which will allow us to price our product at a level that will help grow the market while still achieving >90% margin. We will start by offering access as a service to high value customers, which be followed by a razor and blade model of selling instruments and consumables.

XGenomes's YC application, reconstructed

Y Combinator application

XGenomes, Winter 2019 batch. The real form questions, answered from public data.

  1. Founders2
  2. Company7
  3. Progress7
  4. Idea4
  5. Equity3
  6. Curious2
  7. Batch Preference1

Company

Company name

XGenomes

Describe what your company does in 50 characters or less.

Building the sequencing technology of the future

What is your company going to make? Please describe your product and what it does or will do.

We are building a DNA sequencing platform that sequences directly on unmodified single DNA molecules, with zero library preparation. Our technology integrates DNA extraction with sequencing and reads both strands simultaneously for high accuracy. It produces complete sequences covering structural variants and repetitive regions that current methods miss, and aims to lower consumable costs below $10.

Where do you live now, and where would the company be based after YC?

We live and work in Boston and Cambridge, MA, and plan to keep the company based here after YC.

Explain your decision regarding location.

We chose Boston and Cambridge because of the rich biotech ecosystem and access to top scientific and engineering talent needed for developing novel sequencing technology.

21 more answers in the full application

Founders, Progress, Idea, Equity, Curious, Batch Preference are in the full version. Create a free account to open it in YC Insights, next to every other YC batch.

Frequently Asked Questions

Is this the real XGenomes YC application?

No. Y Combinator keeps submitted applications private. This is a reconstruction: the real YC form questions, answered from XGenomes's public data (launch notes, founder backgrounds, product description). It shows how a company like XGenomes would present itself to YC, not the text they submitted.

What YC batch was XGenomes in?

XGenomes was part of the Y Combinator Winter 2019 batch.

Who founded XGenomes?

XGenomes was founded by Kalim Mir.

What does XGenomes do?

XGenomes is building the sequencing technology of the future.

How do I read the full reconstructed application?

Create a free Round Funded account. The full 26-answer version of XGenomes's application, and every other YC batch, is in YC Insights.

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